According to me, one of the most interesting aspects of Renaissance painting is the artists' focus on anatomy. Similar to Alberti's approach, Renaissance artists combined both painting and science. They discovered human body in a visual way.
Do you think is it necessary to observe human anatomy while creating an artwork?
http://www.metmuseum.org/toah/hd/anat/hd_anat.htm
“There were lots of investigative anatomists around at the time, and there were lots of artists who were interested in anatomy. But Leonardo pushed these two things further than anybody else. He was the supreme example of an anatomist who could also draw, or of an artist who was also a very skilled dissector. It was the union of these two skills in a single figure that made Leonardo unique.” says Martin Clayton (head of prints and drawings in the Royal Collection). I think Da Vinci is the best.
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